By Errol C Friedberg
With a Foreword by means of Sydney Brenner (Nobel laureate in body structure or drugs, 2002)
This biography info the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's existence from start, in 1926, to the current, with unique emphasis on his huge, immense clinical contributions, together with being the 1st to advance know-how that ended in gene cloning technological know-how. In 1980, Berg acquired a Nobel Prize in chemistry for this work.
In addition to his contributions within the learn laboratory, Berg orchestrated and oversaw a historical assembly at Asilomar, California that established on a threatening controversy surrounding the conception by way of many of the destructive power of recombinant DNA expertise. This assembly did a lot to prevent this controversy and to install position the law of recombinant DNA paintings, therefore placing fears to rest.
The recombinant DNA controversy was once a historical final result of the invention of gene cloning. significantly, it represented a paramount instance of medical foresight and due diligence by way of the medical group, instead of through regulatory entities within the usa and lots of different nations. the final word reputation of gene/DNA cloning resulted in a brand new period of recent biology that prospers to the present.
This e-book is aimed basically at scientists and people in education. The e-book strives to easily offer details for the final reader, yet isn't really in particular adapted for a normal interpreting audience.
While many books disguise the recombinant DNA controversy, none have satisfactorily addressed this old interval and are usually contradictory concerning the many who is, where's, and why's concerned. also, the nice majority of those have been written by way of non-scientists. This biography of Paul Berg presents entry to varied archived letters and records at Stanford college now not formerly addressed, and to the chronology of occasions as recalled and documented by way of him, in addition to different key personalities, a lot of whom have been interviewed.
- Part I:
- Growing Up in Brooklyn
- The crucial Paul Berg
- College — and global battle II
- Western Reserve University
- Part II:
- Washington collage, St. Louis
- Discovering move RNA
- Stanford college — and Its Refurbished division of Biochemistry
- Transcription and Translation: New Directions
- Part III:
- Making Recombinant DNA — the 1st Faltering Steps
- Making Recombinant DNA — a huge Breakthrough
- EcoRI limit Endonuclease — a huge Breakthrough
- “Coincidence is the observe We Use once we cannot See the Levers and Pulleys”
- Yet one other Stanford Contribution
- Part IV:
- An ancient assembly in Hawaii
- The Recombinant DNA Controversy
- A Momentous Gordon study Conference
- Making Recombinant Molecules with Frog DNA
- The Controversy Heats Up
- Asilomar II
- The Dissenters: a special element of View
- The Aftermath
- Legislative and Revisionist demanding situations to Recombinant DNA
- Asilomar II — classes Learned
- Part V:
- The Nobel Prize in Chemistry
- Commercializing the Technology
- Life is going on
- The “Retirement” Years
- Public coverage matters — and different Interests
- Personal Challenges
Readership: Researchers, graduate scholars, undergraduates in existence sciences, medication and chemistry and lay public.
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